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Fosphenytoin sodium
CAS No. 92134-98-0
Fosphenytoin sodium( ACC-9653 )
Catalog No. M20300 CAS No. 92134-98-0
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 74 | In Stock |
|
| 50MG | 87 | In Stock |
|
| 100MG | 140 | In Stock |
|
| 500MG | 348 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFosphenytoin sodium
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NoteResearch use only, not for human use.
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Brief DescriptionFosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.
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DescriptionFosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.(In Vivo):Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).
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In Vitro——
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In VivoFosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).
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SynonymsACC-9653
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaNeurological Disease
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IndicationNeuropathic pain
Chemical Information
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CAS Number92134-98-0
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Formula Weight406.24
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Molecular FormulaC16H13N2Na2O6P
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Purity>98% (HPLC)
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SolubilityH2O:100 mg/mL (246.16 mM)
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SMILES[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Smith R D Brown B S Maher R W et al. Pharmacology of ACC‐9653 (Phenytoin Prodrug)[J]. Epilepsia 2010 30(s2):S15-S21.
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